Remdesivir and COVID-19 proofreading enzyme.png

August 3, 2021

The coronavirus that causes COVID-19 has demonstrated a stubborn ability to resist most nucleoside antiviral treatments, but a new study led by an Iowa State University scientist, Dr. Yang Yang, could help to overcome the virus’s defenses.

The process of multidrug-activated transcription visualized by cryo-EM

May 11, 2021

The rapid emergence of antibiotic resistance in bacteria is a major global challenge. A better understanding of the molecular mechanism governing the gene expression regulation by the multidrug-sensing MerR family regulators in response to diverse drug molecules is critical for the treatment of bacterial infections. In our lab's new study, we reported one crystal structure of a multidrug-sensing MerR family regulator EcmrR and nine cryo-EM structures that capture the EcmrR-dependent transcription process from promoter opening to initial transcription to RNA elongation. Our findings provide a comprehensive model for transcription regulation by the MerR family regulators, with broad mechanistic implications for multidrug resistance in bacteria.