Publications

• Liu C#, Shi W, Becker ST, Schatz DG, Liu B#, Yang Y# (2021). Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme. Science 373(6559) 1142-1146 (# Corresponding authors)​

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• Shi W, Zhou W, Chen M, Yang Y, Hu Y, Liu B (2021) Structural basis for activation of Swi2/Snf2 ATPase RapA by RNA polymerase. Nucleic Acids Res 49(18):10707-10716

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• Du L, Yang Y, Zhang X (2021). Neutralizing antibodies for the prevention and treatment of COVID-19. Cell Mol Immunol 18(10):2293-2306

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• Yang Y#, Liu C#, Zhou W, Shi W, Chen M, Zhang B, Schatz DG, Hu Y#, Liu B# (2021). Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun 12: 2702 (# Corresponding authors)

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• Shi W, Zhang B, Jiang Y, Liu C, Zhou W, Chen M, Yang Y#, Hu Y#, Liu B# (2021). Structural basis of copper-efflux-regulator-dependent transcription activation. iScience 24 (5): 102449 (# Corresponding authors)

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• Yang Y, Du L (2021). SARS-CoV-2 spike protein: a key target for eliciting persistent neutralizing antibodies. Signal Transduct Target Ther 6(1):95

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• Yang Y#, Harris KA, Widner DL, Breaker RR# (2021). Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex. Proc Natl Acad Sci U S A 118: e2020393118 (# Corresponding authors)

2020

• Jiang S, Zhang X, Yang Y, Hotez PJ, Du L (2020). Neutralizing antibodies for the treatment of COVID-19. Nat Biomed Eng 4, 1134–1139

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• Shang J, Wan Y, Liu C, Yount B, Gully K, Yang Y, Auerbach A, Peng G, Baric RS, Li F (2020). Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry. PLoS Pathog 16: e1008392

2019

• Liu C*, Yang Y*, Schatz DG (2019). Structures of a RAG-like transposase during cut-and-paste transposition. Nature 575(7783): 540-544. (*Co-first authors)
  Nature News & Views: Snapshots of a genetic cut-and-paste
  F1000 recommendation

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• Zhou Y, Yang Y, Huang J, Jiang S, & Du L (2019). Advances in MERS-CoV Vaccines and Therapeutics Based on the Receptor-Binding Domain. Viruses 11(1), 60

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• Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P, Liu X (2019) Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. J Med Chem 62 (3): 1484-1501

2018

• Zheng Y*, Shang J*, Yang Y*, Liu C, Wan Y, Geng Q, Wang M, Baric RS, Li F (2018) Lysosomal proteases are a determinant of coronavirus tropism. J Virol 92: e01504-18 (*Co-first authors)

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• Yang Y*, Kang D*, Nguyen LA, Smithline ZB, Pannecouque C, Zhan P, Liu X, Steitz TA (2018) Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-d]pyrimidine non-nucleoside inhibitors. eLife 7: e3634
  YaleNews: New compound targets drug-resistant HIV mutants

• Gunaratne GS, Yang Y, Li F, Walseth TF, Marchant JS (2018) NAADP-dependent Ca2+ signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system. Cell Calcium 75: 30-41
  F1000 recommendations

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• Shang J*, Zheng Y*, Yang Y*, Liu C, Geng Q, Luo C, Zhang W, Li F (2018) Cryo-EM structure of infectious bronchitis coronavirus spike protein reveals structural and functional evolution of coronavirus spike proteins. PLoS Pathog 14: e1007009 (*Co-first authors)

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• Shang J*, Zheng Y*, Yang Y*, Liu C, Geng Q, Tai W, Du L, Zhou Y, Zhang W, Li F (2018) Cryo-Electron Microscopy Structure of Porcine Deltacoronavirus Spike Protein in the Prefusion State. J Virol 92: e01556-17 (*Co-first authors)

2017

• Chan JD, Cupit PM, Gunaratne GS, McCorvy JD, Yang Y, Stoltz K, Webb TR, Dosa PI, Roth BL, Abagyan R, Cunningham C, Marchant JS (2017) The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligand. Nat Commun 8: 1910
  F1000 recommendation

• Joshi S, Chen L, Winter MB, Lin YL, Yang Y, Shapovalova M, Smith PM, Liu C, Li F, LeBeau AM (2017) The Rational Design of Therapeutic Peptides for Aminopeptidase N using a Substrate-Based Approach. Sci Rep 7: 1424

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• Peng G*, Yang Y*, Pasquarella JR, Xu L, Qian Z, Holmes KV, Li F (2017) Structural and Molecular Evidence Suggesting Coronavirus-driven Evolution of Mouse Receptor. J Biol Chem 292: 2174-2181 (*Co-first authors)

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• Du L, Yang Y, Zhou Y, Lu L, Li F, Jiang S (2017) MERS-CoV spike protein: a key target for antivirals. Expert Opin Ther Targets 21: 131-143

2016

• Du L*, Tai W*, Yang Y*, Zhao G, Zhu Q, Sun S, Liu C, Tao X, Tseng CK, Perlman S, Jiang S, Zhou Y, Li F (2016) Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines. Nat Commun 7: 13473 (*Co-first authors)

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• Liu C*, Ma Y*, Yang Y*, Zheng Y, Shang J, Zhou Y, Jiang S, Du L, Li J, Li F (2016) Cell Entry of Porcine Epidemic Diarrhea Coronavirus Is Activated by Lysosomal Proteases. J Biol Chem 291: 24779-24786 (*Co-first authors)

2015

• Yang Y*, Liu C*, Du L, Jiang S, Shi Z, Baric RS, Li F (2015) Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus. J Virol 89: 9119-9123

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• Liu C, Tang J, Ma Y, Liang X, Yang Y, Peng G, Qi Q, Jiang S, Li J, Du L, Li F (2015) Receptor usage and cell entry of porcine epidemic diarrhea coronavirus. J Virol 89: 6121-6125

2014

• Liu C*, Yang Y*, Chen L, Lin YL, Li F (2014) A unified mechanism for aminopeptidase N-based tumor cell motility and tumor-homing therapy. J Biol Chem 289: 34520-34529 (*Co-first authors)

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• Ma C, Wang L, Tao X, Zhang N, Yang Y, Tseng CK, Li F, Zhou Y, Jiang S, Du L (2014) Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments--the importance of immunofocusing in subunit vaccine design. Vaccine 32: 6170-6176

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• Yang Y*, Du L*, Liu C*, Wang L, Ma C, Tang J, Baric RS, Jiang S, Li F (2014) Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus. Proc Natl Acad Sci U S A 111: 12516-12521

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• Du L*, Zhao G*, Yang Y*, Qiu H, Wang L, Kou Z, Tao X, Yu H, Sun S, Tseng CT, Jiang S, Li F, Zhou Y (2014) A conformation-dependent neutralizing monoclonal antibody specifically targeting receptor-binding domain in Middle East respiratory syndrome coronavirus spike protein. J Virol 88: 7045-7053 (*Co-first authors)

2013

• Chen Y*, Rajashankar KR*, Yang Y*, Agnihothram SS, Liu C, Lin YL, Baric RS, Li F (2013) Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus. J Virol 87: 10777-10783 (*Co-first authors)

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• Yang Y, Liu C, Lin YL, Li F (2013) Structural insights into central hypertension regulation by human aminopeptidase A. J Biol Chem 288: 25638-25645